Limb-threatening or essential limb ischemia (CLI) is manifested by Long-term (much more than two weeks) ischemic rest soreness, ischemic wounds or tissue reduction, or gangrene in a single or both legs. Ischemic relaxation agony usually happens before long following slipping asleep; the individual is awakened by burning soreness or numbness https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/