There's a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to lessen afferent discomfort transmission and generate analgesia. For that reason, medications like clonidine that focus on alpha-two receptors can influence the transmission of discomfort. Applies to clonidine: oral pill, https://www.proleviate.com/post/the-new-pain-killer-conolidine